Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance

By J. MacKeigan, Leon O. Murphy, J. Blenis. Nature Cell Biology, 2005

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Protein-tyrosine phosphatases and cancer (2006, background): “Finally, pro-apoptotic functions of DEP1 have also been described that might contribute to its tumour-suppressive functio”
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. (2007, background): “, 2005), and IKBKE suppression in HeLa cells leads to apoptosis (Adli and Baldwin, 2006; MacKeigan et al., 2005).”
Protein tyrosine phosphatases: from genes, to function, to disease (2006, background): “The description of the 'PTP-ome' will now facilitate functional analyses of the family as a whole, for example by RNA”
From promiscuity to precision: protein phosphatases get a makeover. (2009, background): “A high throughput RNAi screen for kinases and phosphatases that regulate apoptosis identified 73 kinases and 72 phosphatase genes (including 20 PPP regulatory subunit genes) as potential regulators of cell survival (MacKeigan et al., 2005).”
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. (2006, background): “, 2003) and cell survival (Mackeigan et al., 2005) as well as kinases required for clathrinand caveolae-mediated endocytosis (Pelkmans et al.”