Glutathione: new roles in redox signaling for an old antioxidant
By K. Aquilano, S. Baldelli, M. Ciriolo. Frontiers in Pharmacology, 2014
824 citations recorded by the source corpus.
The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
Subfields: Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/59243ca8a6eee51680e942464519d7406b631d43
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In Molecular Biology
Citations in the corpus
- Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases (2018, background): “Alteration of glutathione concentration has been linked to adverse health impacts such as dysregulation of cell proliferation, transcription of detoxification enzymes, and apoptosis (Aquilano et al., 2014).”
- NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism (2018, background): “Since the critical roles of GSH in redox stress (oxidative and reductive stress) have been extensively discussed elsewhere (6, 110, 117), in the context of this review, we primarily focus on the NAD(H) and NADP(H) redox couples.”