The changing faces of glutathione, a cellular protagonist.

By A. Pompella, A. Visvikis, A. Paolicchi, V. De Tata, A. Casini. Biochemical Pharmacology, 2003

1,337 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/be7aaba732682d18cd2ac64bc4d2efe25b0497be

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Citations in the corpus

CuO and ZnO nanoparticles: phytotoxicity, metal speciation, and induction of oxidative stress in sand-grown wheat (2012, background): “The role of GSH as a major protectant against ROS (Apel and Hirt 2004; Pompella et al. 2003; Sies 1999) agreed with our finding of higher levels of GSSG in the NP-exposed plants.”
Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. (2005, background): “In addition, GSH may be covalently bound to proteins through a process called glutathionylation and acts as a coenzyme of numerous enzymes involved in cell defense [93].”
Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity. (2017, background): “GSH is capable of preventing damage to important cellular components, and GPx plays a major part in cellular metabolism and free radical scavenging by consuming GSH (Pompella et al., 2003; Pena-Llopis et al., 2003).”
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022, background): “GSH plays a critical role in protecting cells from oxidative damage through direct antioxidant activity or coupled to GPx enzymatic activity [37,38].”
The role of glutathione in cancer (2004, background): “In an interesting paradox, the interaction of GSH with metal ions can also lead to an overall ‘oxidizing’ effect, by the generation of superoxide anions from the transfer of electrons from the metal ions to molecular oxygen.(37) Cleavage of the -glutamyl bond in GSH by membrane-bound -glutamyltranfe”
Antibacterial activity of graphite, graphite oxide, graphene oxide, and reduced graphene oxide: membrane and oxidative stress. (2011, background): “can prevent damages to cellular components caused by oxidative stress.(35) Thiol groups ( SH) in GSH can be oxidized to disulfide bond ( S S ), which converts GSH to glutathione disulfide.”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “GSH is a tripeptide and the major endogenous antioxidant produced by cells and helps to protect cells from ROS such as free radicals and peroxides [89].”