Regulation of the immune response by the aryl hydrocarbon receptor

By Cristina Gutiérrez-Vázquez, F. Quintana. Immunity, 2018

857 citations recorded by the source corpus.

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is activated by small molecules provided by the diet, microorganisms, metabolism and pollutants. AhR is expressed by a number of immune cells, and thus, AhR signaling provides a molecular pathway that integrates the effects of the environment and metabolism on the immune response. Studies have shown that AhR signaling plays important roles in the immune system in health and disease. As its activity is regulated by small molecules, AhR also constitutes a potential target for therapeutic immunomodulation. In this review we discuss the role of AhR in the regulation of the immune response in the context of autoimmunity, infection and cancer, as well as the potential opportunities and challenges of developing AhR targeted therapeutics.

Subfields: Biological Psychiatry, Immunology

View Paper: https://www.semanticscholar.org/paper/0533d3f3d989a97d4f204700b366ea9a39ae90d9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. F. Quintana
2. Michael A. Wheeler

In Immunology

1. Michael A. Wheeler
2. M. Linnerbauer
3. F. Quintana

Citations in the corpus

• Astrocyte crosstalk in CNS inflammation (2020, background): “One of these mechanisms involves the ligand- activated transcription factor aryl hydrocarbon receptor (AHR), whose activity is modulated by small molecules provided, for example, by cellular and commensal flora metabolism (Gutiérrez-Vázquez and Quintana, 2018; Wheeler et al., 2017) (Fig.”