Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

By J. Buckner. Nature reviews. Immunology, 2010

822 citations recorded by the source corpus.

A lack of regulatory T (TReg) cells that express CD4, CD25 and forkhead box P3 (FOXP3) results in severe autoimmunity in both mice and humans. Since the discovery of TReg cells, there has been intense investigation aimed at determining how they protect an organism from autoimmunity and whether defects in their number or function contribute to the development of autoimmunity in model systems. The next phase of investigation — that is, to define the role that defects in TReg cells have in human autoimmunity — is now underway. This Review summarizes our progress so far towards understanding the role of CD4+CD25+FOXP3+ TReg cells in human autoimmune diseases and the impact that this knowledge might have on the diagnosis and treatment of these diseases.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4173d82cfb9a647046e57c2e1be605c290ba5c30

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In Immunology

Citations in the corpus

Immunology of Psoriasis (2014, background): “Buckner (80) recently reviewed how a healthy immune state is a consequence of effector T cells being held in check by Tregs, leading to a balanced immune status.”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Yet detailed knowledge might be important for therapeutic interventions in certain T cell-mediated diseases, as resistance of effector T cells to Treg-mediated suppression frequently occurs in autoimmune diseases (Buckner, 2010).”
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection (2012, background): “, 2002), a pathology that has been linked to defective Treg function (Buckner, 2010).”