Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

By J. Tzartos, M. Friese, M. Craner, J. Palace, J. Newcombe, M. Esiri, L. Fugger. American Journal of Pathology, 2008

1,225 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e1df4280e4cdb8f6a381e64739eab966773572e3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Sallusto
2. A. Lanzavecchia
3. Dan R. Littman
4. Michael A. Wheeler
5. M. Linnerbauer
6. F. Quintana
7. Hans Lassmann
8. B. Engelhardt

In Oncology

1. F. Sallusto
2. A. Lanzavecchia
3. Hans Lassmann
4. Dan R. Littman

In Pathology and Forensic Medicine

1. Hans Lassmann
2. Dan R. Littman

Citations in the corpus

• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “Tzartos and collaborators have shown the presence of IL-17-positive perivascular lymphocytes in brain lesions from patients with active MS and a reduction of these cells in quiescent MS (Tzartos et al., 2008).”
• MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis (2009, background): “, and IL-17-expressing T cells have been found in lesions of brain tissues from patients with multiple sclerosi”
• C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE (2009, background): “In addition, IL-17 + T cells have been found in lesions in brain tissues from patients with multiple sclerosi”
• Multiple Sclerosis Pathology. (2018, background): “One study reported Il17 expression in CD4+ and CD8+ lymphocytes (Tzartos et al. 2008, 2011), but functional interpretation of these findings was complicated by the abundance of the expression of Il17 in astrocytes.”
• Astrocyte crosstalk in CNS inflammation (2020, background): “Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis.”
• The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt (2008, background): “IL-17 and CD4 + T H -17 cells are found in lesions from multiple sclerosis patient”