Multiple sclerosis: a complicated picture of autoimmunity

By H. McFarland, Roland Martin. Nature Immunology, 2007

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Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “These T cells are capable of producing inflammatory cytokines and may be differentiated or have the potential to differentiate on activation into Th1 (producing IFN-gamma) or Th17 cells (IL-17, IL-22, IL-21) or cells producing both (McFarland and Martin, 2007).”
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases (2010, positive): “The pathogenic CD4 + T cells in multiple sclerosis target myelin-based antigens, have the ability to migrate to the CNS and have unique effector function”
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “Inflammation and apoptosis Studies of the neuroprotective roles of HDAC inhibitors, which are known to broadly affect gene expression within the immune system, have been extended to other diseases that involve inflammation and neuronal apoptosis, such as multiple sclerosi”
Autoimmune T cell responses in the central nervous system (2009, background): “Multiple sclerosis is the most common of these diseases, affecting more than one million people worldwid”
The pathobiology of vascular dementia (2013, positive): “Multiple sclerosis (MS) is the prototypical neuroinflammatory disease in which demyelination is thought to be related to a T cell mediated autoimmune attack on myelin (McFarland and Martin, 2007).”