P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing

By A. Eulalio, I. Behm-Ansmant, D. Schweizer, Elisa Izaurralde. Molecular and Cellular Biology, 2007

726 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ef69c91b8dbbd29640fd09d3a65219bbdc87712f

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In Molecular Biology

Citations in the corpus

MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “Interestingly, HeLa cells in which P-bodies have been disrupted by depletion of the P-body component LSM1 retain functional miRNA-mediated repressio”
The role of disordered protein regions in the assembly of decapping complexes and RNP granules (2013, background): “These RNP granules contain a variety of proteins involved in mRNA degradation, translational repression, mRNA surveillance, and RNA-mediated gene silencing together with their mRNA targets (Eulalio et al. 2007a; Parker and Sheth 2007).”
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons. (2017, background): “Moreover, translation repressors, but not decay machineries, are essential for P-body formation (Ayache et al., 2015), and P-bodies can be disrupted without preventing decay (Eulalio et al., 2007; Stoecklin et al., 2006).”
RNA granules: post-transcriptional and epigenetic modulators of gene expression (2009, background): “Although this supercomplex can degrade its component mRNA, it can also aggregate with related mRNPs to produce a PB, which in metazoans requires the RISC machiner”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “Furthermore, P-bodies form in an RNA-dependent manner as a consequence of RNAi and RNA degradation (80).”
Origins and Mechanisms of miRNAs and siRNAs (2009, background): “in dispersal of the GW bodies with no effect on miRNA activities (Eulalio et al., 2007).”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “These findings indicate that microscopically visible P bodies are not essential for the repression and that the presence of large P-body aggregates is a consequence rather than the cause of miRNA-induced silencing (170).”
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. (2009, background): “Though P-body integrity (as judged by light microscopy) is not essential for miRNA function [70,71 ], many of the P-body components were shown to play an important role in miRNA-mediated repression [10–12,53,62,70,72].”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “However, because depletion of Edc3 does not block P-body assembly in Drosophila S2 cells (Eulalio et al. 2007b), one anticipates that Q/N domains, and possibly other mechanisms, contribute to metazoan P-body assembly.”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “While P-body formation results from miRNA repression, the loss of components required for visible P-body assembly in animals has no effect on miRNAmediated silencing (Chu and Rana, 2006; Eulalio et al., 2007b).”
Getting to the root of miRNA-mediated gene silencing. (2008, background): “More recently, however, several reports showed that animal miRNAs do induce significant degradation of target mRNAs (Bagga et al., 2005; Wu and Belasco, 2005; Behm-Ansmant et al., 2006; Giraldez et al., 2006; Wu et al., 2006; Chendrimada et al., 2007; Eulalio et al., 2007a).”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “Note also that the knockdown of some P-body components (such as LSM1 or LSM3 ), which results in dispersion of microscopic P-bodies, has no effect on miRNA functio”