Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

By W. Filipowicz, S. Bhattacharyya, Nahum Sonenberg. Nature reviews genetics, 2008

5,381 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b8ccd610162e268f49564695b64f06ea7d21957f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Biogenesis of small RNAs in animals (2009, background): “The functions of small RNAs range from heterochromatin formation to mRNA destabilization and translational contro”
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets (2009, unknown): “Even for those studies concluding that inhibition occurs at the level of translation initiation, the data are conflicting as in some studies translation inhibition was cap dependent and mediated by eIF4F, whereas in others it was cap independent and mediated via eIF6 (Filipowicz et al., 2008).”
Silencing of microRNA families by seed-targeting tiny LNAs (2011, background): “786" language="eng" relation="no"> miRNAs are ∼22-nucleotide non-coding RNAs that regulate gene expression post-transcriptionally by mediating translational repression or promoting degradation of their target mRNA”
Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells (2009, unknown): “In addition to mRNA destabilization, miRNAs can also direct translational repression of their target mRNAs, which adds to their impact on protein output (Lee et al., 1993; Wightman et al., 1993; Filipowicz et al., 2008).”
The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. (2013, unknown): “[87].”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “Complementary base-pairing of the miRNA guides RISC to target messenger RNAs, which are degraded, destabilized or translationally inhibited by the Ago protei”
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. (2009, background): “Introduction MicroRNAs (miRNAs) are an evolutionarily conserved class of small noncoding RNAs that have recently gained status as important regulators of gene expression in diverse biological processes including cellular proliferation, differentiation, and tumorigenesis (1).”
MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis (2019, background): “MicroRNAs (miRNAs) are small, endogenously-initiated non-coding RNAs of about 22 nucleotides that post-transcriptionally control gene expression via either translation inhibition or degradation of their target mRNAs [1, 2].”
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. (2011, background): “miRNAs act in complex with Argonaute (Ago) proteins as part of the RNA-induced silencing complex (RISC) to induce mRNA degradation or repress translation (Baek et al., 2008; Selbach et al., 2008; Filipowicz et al., 2008).”