Getting to the root of miRNA-mediated gene silencing.

By A. Eulalio, Eric Huntzinger, Elisa Izaurralde. Cell, 2008

1,065 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6298d3658f9a73910dd5c5dffa0200f8a1a2854a

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Citations in the corpus

Gene silencing by microRNAs: contributions of translational repression and mRNA decay (2011, background): “; however, the mechanisms that miRNAs use to regulate gene expression remain unclear and several controversies surround the topi”
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. (2009, background): “Generally, miRNAs inhibit protein synthesis either by repressing translation or by bringing about deadenylation and degradation of mRNA targets [1,2,4].”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “This complex minimally consists of three components: an active miRNA strand associated with an AGO protein and a GW182 protei”
microRNA-122 stimulates translation of hepatitis C virus RNA (2008, background): “The EMBO Journal (2008) 27, 3300–3310. doi:10.1038/ emboj.2008.244; Published online 20 November 2008 Subject Categories: proteins; microbiology & pathogens Keywords: 50-UTR; HCV; IRES; microRNA; translation”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “It is difficult to conclude whether the reported discrepancies are artifacts of different experimental approaches or whether miRNAs are indeed able to exert their repressive effects by disparate mechanisms (5, 8, 9, 23).”
Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. (2014, background): “MicroRNAs (miRNAs) are an abundant class of small, non-coding RNAs that regulate gene expression at the levels of mRNA stability and translation (Pillai et al., 2005; Eulalio et al., 2008; Guo et al., 2010).”
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC (2012, background): “DCP2 decapping complex and the mRNA is degraded by the Xrn1 5′–3′ exonuclease (3).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Target degradation can be achieved by deadenylation from the 3’ end or by decapping of the 5’ end attracting endonucleolytic and exonucleolytic activities (71).”
The many pathways of RNA degradation. (2009, background): “This results in decreased translation and increased 50 and 30 degradation (see Figure 2 and Eulalio et al., 2008; Wu and Belasco, 2008).”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “The repression of targeted messages is a common outcome of RISC recruitment and might occur through translational inhibition, accelerated exonucleolytic mRNA decay or site-specific endonucleolytic cleavage (slicing) in miRNA–mRNA pair”
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp™ (2014, background): “MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that regulate gene expression at the levels of mRNA stability and translation (Pillai et al., 2005; Eulalio et al., 2008; Guo et al., 2010).”
Viruses, microRNAs, and Host Interactions (2010, background): “RISC-bound mRNAs often localize to cytoplasmic processing bodies (P bodies), which exclude the translational machinery and contain proteins involved in mRNA remodeling, decapping, and deadenylation, as well as exonucleases (8, 34).”
Origin, biogenesis, and activity of plant microRNAs. (2009, positive): “Repression of the target transcript by miRNAs may occur through translational inhibition, accelerated exonucleolytic mRNA decay, or slicing within miRNA-mRNA base pairing (Eulalio et al., 2008).”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “Complementary base-pairing of the miRNA guides RISC to target messenger RNAs, which are degraded, destabilized or translationally inhibited by the Ago protei”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “Another possible mechanism of translation initiation blocking is the Ago interference with the formation of closed-loop mRNA, achieved through interaction between cytoplasmic poly(A) binding protein and cytoplasmic cap binding protein, by an ill-defined mechanism that may include deadenylation [73] ”