P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.
By C. J. Decker, R. Parker. Cold Spring Harbor Perspectives in Biology, 2012
754 citations recorded by the source corpus.
Subfields: Cognitive Neuroscience, Social Psychology
View Paper: https://www.semanticscholar.org/paper/fb4bde61bef12d5fd6414b859f260038226926b0
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In Cognitive Neuroscience
Citations in the corpus
- P-Body Purification Reveals the Condensation of Repressed mRNA Regulons. (2017, background): “In some models, these mRNAs are targeted to P-bodies for decay (Decker and Parker, 2012).”
- Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, background): “For example, mRNAs are packed in processing or stress bodies under stress conditions, and after stress the mRNA can be released and return to translation or become degraded (42).”
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function (2015, background): “This possibility is distinctly likely because both TIA-1 and mutant FUS are present in stress granules, which act as translational repressors (Anderson and Kedersha, 2002; Bosco et al., 2010; Decker and Parker, 2012).”
- Liquid-liquid phase separation in biology. (2014, background): “…ribosomes inside the nucleus (Boisvert et al. 2007); centrosomes (Mahen & Venkitaraman 2012), which nucleate microtubules; Cajal bodies, which make spliceosomes (Gall 2003); and stress granules (Buchan & Parker 2009, Decker & Parker 2012), which take various forms under different stress conditions.”
- Compositional Control of Phase-Separated Cellular Bodies (2016, positive): “P bodies assemble through multivalent interactions of RNA binding proteins composed of modular RNA binding domains and self-associating disordered regions and mRNA molecules (Decker and Parker, 2012). mRNAs that have exited translation act as important P body scaffolds (Teixeira et al., 2005).”