The role of disordered protein regions in the assembly of decapping complexes and RNP granules
By S. Jonas, Elisa Izaurralde. 2013
198 citations recorded by the source corpus.
Removal of the 5′ cap structure is a critical step in mRNA turnover, yet key questions regarding the assembly and regulation of decapping complexes remain unanswered. This review provides comprehensive insight into the structural and biochemical properties of decapping factors. Jonas and Izaurralde highlight the plasticity of the decapping network and cover recent advances that reveal how short linear motifs (SliMs) in disordered regions help maintain interactions between decapping network members.
Subfields: Molecular Biology
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In Molecular Biology
- R. Parker
- M. Rosen
- Anthony A. Hyman
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- Rohit V. Pappu
Citations in the corpus
- The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, neutral): “Abundant cellular p1dsRNAs also include mRNA degradation and triphosphorylase intermediates (Braun et al., 2012; Choi et al., 2020; Choi and Sullivan, 2021; Jonas and Izaurralde, 2013; Nagarajan et al., 2013; van Dijk et al., 2002).”
- Principles and Properties of Stress granules (2016, background): “Precedent for IDRs functioning as important sites of SLiMs comes from the analysis of Pbodies, where many SLiMs in IDRs contribute to P-body assembly [49].”
- Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly (2017, background): “In some cases, IDRs contain SLiMs that are important for assembly of RNP granules (reviewed in Jonas and Izaurralde, 2013).”
- Formation and Maturation of Phase Separated Liquid Droplets by RNA Binding Proteins (2015, background): “…include those between well-folded domains, as in Edc3 dimerization in yeast P-body assembly (Ling et al., 2008; Decker et al., 2007), and those between short linear motifs (SLiMs) in disordered regions of RNA-binding proteins and other well-folded domains (reviewed in Jonas and Izaurralde, 2013).”
- Liquid-liquid phase separation in biology. (2014, background): “For instance, the degree of disorder and structural flexibility of the protein could be important ( Jonas & Izaurralde 2013, Malinovska et al. 2013).”