LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal.

By Alexandra Capela, Sally Temple. Neuron, 2002

701 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/ec690640ce4943e18ce4422bddc6f7a34565dd93

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Citations in the corpus

Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. (2005, positive): “…or in D Pany cell type of known origin, including oocytes (Figure S2A). t nSince SSEA1 is expressed by some somatic stem cell lineages in adults (Capela and Temple, 2002), we sub- s ejected dispersed adult mouse ovaries to SSEA1-antibody-based magnetic bead sorting (Geijsen et al., a (2004) to…”
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain (2004, methodology): “To allow for easier detection of BrdU and β-tubulin co-localization, we performed double immunofluorescence experiments on dissociated periventricular cells (as reported in Capela and Temple, 2002) (Fig.”
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke (2009, result): “Other studies have instead indicated that forebrain ependymal cells are terminally differentiated glial cell”
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells (2009, background): “, 1999) continues to stir controversy (Capela and Temple, 2002; Chiasson et al., 1999; Doetsch et al., 1999a; Laywell et al., 2000; Spassky et al., 2005).”
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors (2005, background): “These GFAP-expressing cells constitute a pool of stem cell”
Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury (2013, methodology): “…counts were determined using stereological image analysis software (StereoInvestigator or Neurolucida; MicroBrightField) operat- ing a computer-driven microscope regulated in the x-, y-, and z-axes (Zeiss) in a manner described in detail previously (Faulkner et al., 2004; Herrmann et al., 2008).”
Brain tumour stem cells (2006, positive): “The situation is now improving with the identification of cell-surface antigens and methods that are used to identify putative neural stem cells in rodent”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Although unlikely, we acknowledge that ependymoma cancer stem cells could arise from postmitotic ependymal cells that have reacquired the capacity to self-renew (Capela and Temple, 2002; Laywell et al., 2000; Spassky et al., 2005).”
Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions (2008, positive): “SVZ whole mounts from GFAP-GFP mice were stained for ependymal markers, laminin, the nuclear marker DAPI, and, in some cases, the surface marker LeX, which labels the neurosphere-generating cells in the adult SVZ, type B, and type C cells (Capela and Temple, 2002).”
For the long run: maintaining germinal niches in the adult brain. (2004, background): “Blood vessels (BV, pink) are found ronal marker doublecortin (Dcx), suggesting a direct acclose to the SGZ layer, and we propose that a perivascular basal tion of VEGF on neuronal progenitors (Jin et al., 2002).lamina (BL, yellow dotted line) exists here similar to that found in The carbohydrate moi”
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “The antigen SSEA-1, also known as CD15 or LeX, is a fucose-containing trisaccharide highly expressed on embryonic stem cells in the developing brain and adult SVZ (Capela and Temple, 2002, 2006).”