Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

By A. Ferri, Maurizio Cavallaro, D. Braida, A. Di Cristofano, A. Canta, A. Vezzani, S. Ottolenghi, P. Pandolfi, M. Sala, S. Debiasi and 1 more. Development, 2004

709 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a8dc5c6c6aea3a0c8295a10508eff78864b88ad9

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Citations in the corpus

Sox1 marks an activated neural stem/progenitor cell in the hippocampus (2012, background): “By contrast, SOX2 expression has been well characterized in adult neurogenic zones (Ellis et al., 2004; Ferri et al., 2004; Komitova and Eriksson, 2004; Brazel et al., 2005; Episkopou, 2005; Sottile et al., 2006; Suh et al., 2007).”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “In mice, hypomorphic Sox2 mutants, expressing 30% of normal Sox2 levels, show a loss of striatal and thalamic tissue, epilepsy and neurodegeneratio”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “Sox2 is expressed in embryonic and adult stem cells, and functions to maintain neural stem cells in their undifferentiated state (Graham et al., 2003; Ferri et al., 2004).”
TGFβ signalling: a complex web in cancer progression (2010, background): “Independently of this mechanism, TGFβ induces the expression of SOX2 , a self-renewal gene that helps to maintain stem cell-like properties in embryonic stem cells and neural stem cell”
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009, neutral): “The HMG-box transcription factor Sox2 is expressed in embryonic stem cells and most uncommitted cells in the developing CN”
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, positive): “…of any of the SoxB1 factors promotes CNS progenitor cell proliferation, whereas depletion of these factors induces cell-cycle exit and onset of differentiation (Bylund et al., 2003; Cavallaro et al., 2008; Ferri et al., 2004; Graham et al., 2003; Kishi et al., 2000; Miyagi et al., 2008).”
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “Sox2 is a SRY-related transcription factor encoding a high-mobility group (HMG) DNA-binding motif, and it is expressed in embryonic stem (ES) cells and neural epithelial cells during development (Avilion et al., 2003; Ferri et al., 2004; Zappone et al., 2000).”