Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

By M. Carlén, K. Meletis, C. Göritz, V. Darsalia, E. Evergren, Kenji Tanigaki, Mario Amendola, F. Barnabé-Heider, Maggie S. Y. Yeung, L. Naldini and 6 more. 2009

467 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “While still under debate, the ependymal cells lining the ventricles have been proposed as a reservoir of neural stem cells that are recruited after injury (Carlén et al., 2009; Coskun et al., 2008; Mirzadeh et al., 2008).”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, unknown): “A number of cell types have been proposed to serve as putative neural stem cells in the adult brain, including GFAP+ radial precursors (Doetsch et al., 1999; Seri et al., 2001), Sox2+ nonradial precursors (Suh et al., 2007), and SVZ ependymal cells in response to injury (Carlén et al., 2009).”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, unknown): “Nondividing ependymal cells lining the ventricle are multiciliated, and their motile cilia contribute to the flow of cerebrospinal fluid (Spassky et al., 2005; Sawamoto et al., 2006; Carlén et al., 2009; Mirzadeh et al., 2010a).”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “It was recently reported that in the absence of Rbpj or in response to stroke, ependymal cells the enter cell cycle and differentiate into neurons, leading to collapse of the lateral ventricles (Carlén et al., 2009).”
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. (2010, background): “Conversely, multiciliated ependymal cells have been found to be largely quiescent and rarely form self-renewing neurospheres (Capela and Temple, 2002; Carlén et al., 2009; Coskun et al., 2008).”
Astrocytes: biology and pathology (2009, background): “The source of newly divided scar-forming astrocytes is not well established, and may include mature astrocytes that re-enter the cell cycle as well as progenitor cells in the local parenchyma or in the periventricular regions [30, 33, 37, 77, 133, 141, 226].”
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells (2009, background): “However, recent experiments suggest that ependymal cells contribute to neurogenesis only under patho- logic conditions such as ischemic stroke (Carlen et al., 2009).”
EphB signaling controls lineage plasticity of adult neural stem cell niche cells (2010, methodology): “The recombination was specific to ependymal cells and no recombined cell expressed GFAP, glutamine synthetase, DCX, or the proliferation marker Ki67 (Figures 2E–2H; Carlén et al., 2009).”
Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay For Stem Cells (2011, result): “This finding was not replicated by others (reviewed in Kokovay et al., 2008), and the original groupproposing that ependymal cells form neurospheres has recently published that they do not give rise to neurons under homeostasis (Carlén et al., 2009).”