Brain tumour stem cells

By Angelo Luigi Vescovi, R. Galli, B. Reynolds. Nature Reviews. Cancer, 2006

1,017 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c0dca9604e5f593135659390c6419174a8b90919

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Jeremy N. Rich
2. E. Gould
3. Suzanna Becker

In Genetics

1. Jeremy N. Rich
2. J. Lathia
3. Anita B. Hjelmeland
4. Yibin Kang
5. J. Massagué

In Molecular Biology

1. J. Massagué
2. Yibin Kang
3. Jeremy N. Rich
4. R. Weinberg
5. A. Moustakas
6. I. J. Fidler
7. C. Heldin
8. E. Batlle

Citations in the corpus

• Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, neutral): “jpg" NDATA ITEM> ]> Considerable attention is currently focused on identifyingthe events that lead to the development of so-called 'tumour-initiating cells', as understanding this might facilitate the design of more effective cancer therapie”
• Diffuse glioma growth: a guerilla war (2007, neutral): “vide new targets for therapy [185].”
• MEF promotes stemness in the pathogenesis of gliomas (2012, neutral): “Malignant gliomas are highly aggressive cancers composed of a heterogeneous cell population, a fraction of which exhibits stem-like characteristics (Vescovi et al., 2006 ).”
• Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient (2009, background): “In animal models, regions of the brain with stem cell populations are more sensitive to chemical or viral oncogenesis than areas with a low proportion of proliferating cells [25,26].”
• SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “Since these TSCs/TICs represent only a subpopulation within the whole of the tumor, there is great interest in finding cell-surface markers that will allow the prospective identification and isolation of these cells (Uchida et al., 2000; Vescovi et al., 2006).”
• Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, positive): “…self-renewal and long-term proliferation, the formation of neurospheres , and the ability to differentiate into multiple nervous system lineages (neurons, astrocytes, and oligodendrocytes) (Hemmati et al., 2003; Singh et al., 2003, 2004; Galli et al., 2004; Vescovi et al., 2006; Bao et al., 2006a).”
• Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α (2009, background): “In that CSCs seem to have a central role in tumor initiation and recurrence, it has been suggested that definitive cancer treatment needs to target this population of cells (Reya et al., 2001; Pardal et al., 2003; Bao et al., 2006a; Vescovi et al., 2006; Park et al., 2007).”
• Beyond tumorigenesis: cancer stem cells in metastasis (2007, background): “Researches in brain tumor development also indicate that more committed neural progenitor cells are likely to be the targets of tumorigenic mutations [ 53 ].”