Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors

By Xiuxin Liu, Qin Wang, T. Haydar, A. Bordey. 2005

444 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Hongjun Song
2. Guo-li Ming
3. M. Whitman
4. C. Greer
5. M. Götz
6. Brian Halabisky
7. F. Doetsch
8. M. S. Airaksinen

In Developmental Neuroscience

1. Hongjun Song
2. Guo-li Ming
3. F. Doetsch
4. C. Greer
5. M. Whitman
6. M. Götz
7. Brian Halabisky
8. Allison M. Bond

Citations in the corpus

• Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, unknown): “The production of GABA by immature neuroblasts has been proposed to act as a negative feedback mechanism to control proliferation of primary progenitors, which are closely associated with chains of migrating neuroblasts and are therefore optimally positioned to respond to changes in local GABA conce”
• Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “…cells are depleted by an anti-mitotic treatment, SVZ astrocytes divide to rapidly regenerate the SVZ network of chains (Doetsch et al. 1999a,b), perhaps reflecting loss of feedback inhibition from the neuroblasts onto their ancestors, such as loss of GABA signalling (Liu et al. 2005).”
• Neuronal activity-dependent control of postnatal neurogenesis and gliogenesis (2018, unknown): “Upon release in the LV niche, GABA activates GABAA receptors present on GFAP+ cells and newborn neuroblasts, limiting their proliferation (Liu et al. 2005).”
• Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “GABA, the major inhibitory neurotransmitter of the brain, promotes NSC quiescence by blocking cell-cycle progression (Fernando et al., 2011).”
• GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “Thus, the increased NSC proliferation in apoE4-KI mice likely reflects impaired GABA signaling (Liu et al., 2005; Owens and Kriegstein, 2002; Tozuka et al., 2005).”
• Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo (2007, background): “In the germinative zones of the developing CNS, GABA acts as an autocrine/paracrine excitatory signal to either promote or inhibit cell proliferation, depending on the stage of differentiation of neural progenitors (LoTurco et al., 1995; Haydar et al., 2000; Liu et al., 2005).”
• Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “Electrophysiological studies of the GFAP-GFP mice demonstrate that non-synaptic c-aminobutyric acid (GABA)ergic signaling between neuroblasts and GFAP-expressing cells is involved in the proliferation of GFAP-expressing progenitors (Liu et al., 2005).”