Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

By I. Wanner, Mark A. Anderson, B. Song, J. Levine, A. Fernández, Zachary Gray-Thompson, Y. Ao, M. Sofroniew. Journal of Neuroscience, 2013

743 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/713e068bd28afdd7e7434dad02ee147d0f3e079a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. J. Burda
5. E. Hol
6. A. Tran
7. J. Silver
8. P. Warren

In Developmental Neuroscience

1. M. Pekny
2. M. Pekna
3. J. Burda
4. M. Sofroniew
5. E. Hol
6. C. Farina
7. E. Colombo
8. Alexander M. Bernstein

In Neurology

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. J. Burda
5. E. Hol
6. Alexander M. Bernstein
7. C. Farina
8. E. Colombo

Citations in the corpus

• Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms (2020, background): “The NG2 which expresses OPC cells are termed as NG2-OPC [47].”
• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, methodology): “Ultimately, cell signaling and transcriptional changes following the inflammatory storm enable potentiation of astrocytosis including cyotoskeletal protein expression (262), proliferation (21, 22, 408), and secretion of proinflammatory factors (175) to allow for an adequate wall building response to”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “Notably, these mice showed also a more pronounced functional impairment (95, 163, 256).”
• Spinal cord injury: molecular mechanisms and therapeutic interventions (2023, background): “Although there are also other cell types within the astrocyte scar compartment, such as OPCs, the mature astrocyte scar after SCI consists primarily of newly generated astrocytes.(177,181,182)”
• Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. (2015, background): “Astrocytespecific genetic ablation of STAT3 inhibits lesion demarcation and results in larger lesions and more prominent functional impairment [37 ,38 ,39].”
• Astrocyte roles in traumatic brain injury (2015, background): “dividual cellular domains and have elongated processes that intertwine extensively (Wanner et al., 2013).”
• Astrocytes: Key Regulators of Neuroinflammation. (2016, background): “In the last disease model the spinal cords of transgenic mice are characterized by widespread infiltration of CD11b+ inflammatory cells, pronounced demyelination and neuronal loss due to disorganized scar formation [61,62,65].”
• Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Reactive astrocytes proliferate and mobilize to the site of injury and form a mesh like structure of intermingled filamentous processes around the injury epicenter (284, 285).”
• Astrocyte reactivity: Subtypes, states and functions in CNS innate immunity (2020, background): “Because astrocytes divide rarely in healthy tissue [13], proliferation is an important means of discriminating Sofroniew Page 3”