Radial glia cells are candidate stem cells of ependymoma.

By Michael D. Taylor, H. Poppleton, C. Fuller, Xiao-hu Su, Yongxing Liu, Patricia Jensen, S. Magdaleno, J. Dalton, C. Calabrese, Julian R. Board and 6 more. Cancer Cell, 2005

834 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3988081f83332dd3f78c1928d4e376eaf730944d

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Citations in the corpus

Targeting cancer stem cell pathways for cancer therapy (2020, methodology): “61 successfully isolated CSCs from a variety of neurological tumors by using this colony formation assay.”
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. (2015, background): “Functional cross-species studies provide evidence that these molecular differences reflect regionally discrete cells of origin (Johnson et al., 2010; Parker et al., 2014; Taylor et al., 2005).”
Nanomedicine therapeutic approaches to overcome cancer drug resistance (2013, background): “Cancer stem cells have also been isolated from medulloblastoma, glioblastoma [41], ependymoma [42], colon cancer [43,44], chronic and acute myeloid leukemia [45], pancreatic cancer [46], and head and neck squamous cell carcinomas [47].”
Expression profiling of ependymomas unravels localization and tumor grade‐specific tumorigenesis (2009, background): “A similar pattern of expression was observed by Taylor and coworkers in radial glial fibers, leading to the suggestion that ependymomas derive from regionally specific stem cells bearing a radial glial cell phenotype.(15) When only WHO grade 2 tumors were analyzed, intracranial tumors differed from ”
A perivascular niche for brain tumor stem cells. (2007, methodology): “Previous cytogenetic studies showed that all cultured primary tumor cells were cancer cells (Taylor et al., 2005).”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “Because ependymomas appear to arise from radial glia and are hierarchically organized into tumorigenic and nontumorigenic components (Taylor et al., 2005), these results suggest that regional differences in radial glia lead to regional differences in driver mutations and cancer stem cell properties.”
Cells of origin in cancer (2011, background): “Notably, histologically indistinguishable glial-cell tumours from different parts of the central nervous system have distinct molecular gene signatures and chromosomal abnormalities, suggesting that they originated in different subpopulations of site-restricted progenitor cell”
Tumorigenesis in the brain: location, location, location. (2007, background): “The CSC hypothesis is predicated on the idea that not all cancer cells have equal proliferative potential, and that cells with the greatest ability to proliferate and form new tumors have phenotypic and functional properties similar to NSCs.”
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells (2008, background): “In ependymomas, data suggest that such molecularly distinct subgroups are derived from different populations of progenitor cells.(21) Within the C6 glioma cell line, even CD133 negative cells possess clonogenic, self-renewal and tumorgenic capacities.”
Integrin alpha 6 regulates glioblastoma stem cells (2010, background): “…cells (CSCs), tumor-initiating cells, or tumor-propagating cells, has been found in many tumors (Reya et al., 2001) including brain cancers (Bao et al., 2006a, 2006b; Galli et al., 2004; Hemmati et al., 2003; Ignatova et al., 2002; Singh et al., 2003, 2004; Taylor et al., 2005; Yuan et al., 2004).”
Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation (2008, neutral): “CSC of brain7,16, gut3,4 and pancreatic17 tumors have been isolated using PROM1 antibodies; however, most PROM1 antibodies recognize glycosylation-dependent epitopes that vary with the differentiation and transformation status of the cell18, complicating the use of these reagents to fractionate…”
Brain tumour stem cells (2006, background): “Interestingly, this concept has now been extended to include other brain tumours, such as ependymoma”
The biology of cancer stem cells. (2007, background): “Till & McCulloch (1961) provided the first experimental models that suggested the existence of normal blood stem cells.”
Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “2003) and solid tumors (Al-Hajj et al. 2003; Singh et al. 2004; Sanai et al. 2005; Taylor et al. 2005; Patrawala et al. 2006; Li et al. 2007; O’Brien et al. 2007; Prince et al. 2007).”