Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

By C. Hsieh, Yuqiong Liang, A. Tyznik, S. Self, D. Liggitt, Alexander Y. Rudensky. Immunity, 2004

791 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ec2d1e1d9622c87a73d66fc60fe9ac096b4cb0e8

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In Immunology

Citations in the corpus

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires (2006, neutral): “(4) AASQGGSAKLI (B2) (9) AASGYGSSGNKLI (B33)”
Foxp3 in control of the regulatory T cell lineage (2007, background): “T reg cells are also unable to produce cytokines that promote T H 1 and T H 2 immune responses; this feature is likely to be essential for immune homeostasis, considering the expression of potentially pathogenic self-reactive TCRs on the surface of many T reg cell”
Regulatory T cells in transplantation tolerance. (2005, background): “as an artefact of homeostatic expansion and/or because the repertoire of the natural CD4+CD25+ population is itself dominated by self-reactivity (Hsieh et al. 2004).”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “The resulting TCR repertoires were distinct and only partially overlapping in resemblance of TCR utilization by Foxp3 Treg cells and Foxp3 ‘‘non-Treg’’ CD4 T cells present in unmanipulated mice (Hsieh et al., 2004; Lathrop et al., 2008).”
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells (2010, neutral): “(39) reported the repertoire similarities to be 25%, whereas Pacholczyk et al.”
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. (2007, background): “, 2003) and/or to the inherent self-reactivity of their TCR (Hsieh et al., 2004).”
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice (2006, background): “This may be because the frequency of resident T reg cells specific for foreign antigens such as ovalbumin used in published studies is lower than that for self antigen”
Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, result): “Adding to the controversy, several studies have shown that T reg cell and non–T reg cell TCR repertoires overlap, although the reported extent of the overlap varie”
IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 (2007, background): “It is tempting to speculate that this relates to the higher self-reactivity of TCRs expressed by Tregs (39).”
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “Treg cells are supposed to be headers of tolerance via a TCR repertoire aimed at recognizing self-antigens (135), including TAAs such as melanoma antigens (136).”