Control of regulatory T cell lineage commitment and maintenance
By Steven Z. Josefowicz, Alexander Y. Rudensky. Immunity, 2009
614 citations recorded by the source corpus.
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens, and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/82a6553e5fcb6e9c25805a79a356d936808e5a51
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In Immunology
- Alexander Y. Rudensky
- Dan R. Littman
- Steven Z. Josefowicz
- J. O’Shea
- Ye Zheng
- P. Treuting
- F. Powrie
- F. Quintana
Citations in the corpus
- Oral tolerance (2011, background): “AHR limits the activation of Stat1 during Th17 and Treg differentiation (102, 103), and Stat1 activation antagonizes the differentiation of Foxp3 iTregs (104) but not nTregs (105); indeed several cytokines, signaling pathways and genomic elements have differential contributions to the generation of ”
- Interleukin 12: still a promising candidate for tumor immunotherapy? (2014, background): “regulatory FoxP3 Tab cells [159,160] in a manner similar to IL-7 [22] but less potent than IL-2 [8,22].”
- Extrathymically generated regulatory T cells control mucosal Th2 inflammation (2012, result): “This notion is consistent with data indicating that tT reg cells arise from a subset of thymocytes, which exhibit TCR with an increased affinity for self-antigens yet insufficient for negative selectio”
- Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010, background): “STAT3 Inhibits Regulatory T Cell Conversion Treg cells are a specialized population of CD4 T cells that express the forkhead/winged-helix protein Foxp3, and they dampen inflammatory responses and prevent autoimmunity (Josefowicz and Rudensky, 2009).”
- Plasticity of CD4+ T cell lineage differentiation. (2009, background): “Two major categories of Foxp3+ Treg cells have been identified: the naturally occurring CD4+ CD25+ Treg (nTreg) cells that arise in the thymus and the TGF-b-induced iTreg cells produced in the periphery (Curotto de Lafaille and Lafaille, 2009; Josefowicz and Rudensky, 2009, both in this issue).”