IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1

By M. Burchill, Jianying Yang, Christine Vogtenhuber, B. Blazar, M. Farrar. Journal of Immunology, 2007

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Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? (2009, background): “STAT5 binds to the Foxp3 gene and may cooperate with STAT3 for Foxp3 induction (Burchill et al., 2007; Li and Flavell, 2008).”
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “STAT5 binds to the promoter of the FoxP3 gene and it can promote Treg differentiation by regulating FoxP3 expression [40].”
TGF-beta: a master of all T cell trades. (2008, positive): “, 2007), which activates the transcription factor STAT5 for binding to the Foxp3 promoter (Burchill et al., 2007).”
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “However, defective Treg cell production was also noted in Stat5-deficient mice (Snow et al., 2003; Yao et al., 2007), and this effect was attributed to failed IL-2R signaling in the thymus and periphery (Burchill et al., 2007), emphasizing the important role of this signaling pathway in Treg cells.”