Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

By Ilaria Marigo, L. Dolcetti, P. Serafini, Paola Zanovello, V. Bronte. Immunological Reviews, 2008

624 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e25d59b7a43222c3ffa171f437b9ef50cdc66573

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Citations in the corpus

Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, background): “, immune suppression, when the tumor progresses (Gabrilovich and Nagaraj, 2009; Marigo et al., 2008).”
Microenvironmental regulation of metastasis (2009, background): “MDSCs suppress the adaptive immune response by blocking the functions of CD4 + and CD8 + T cells, in part through arginase and nitric oxide production, by expanding the regulatory T cell pool, and by inhibiting NK cell activatio”
Myeloid derived suppressor cells (2013, background): “43 In a positive feedback cycle, these skewed macrophages can then induce further IL-10 production by MDSCs. MDSC-directed immunosuppression often extends to other cells as well.”
Cancer immunotherapy comes of age (2011, positive): “Myeloid-derived suppressor cells can also be recruited into the tumour, and release additional T-cell suppressors, such as arginase and nitrous oxide synthas”
Cancer as an overhealing wound: an old hypothesis revisited (2008, background): “These cells are abundant in tumours and they strongly inhibit anti-tumour immunit”
The Role of the Anaphylatoxins in Health and Disease (2009, neutral): “MDSC are a heterogeneous population of regular myeloid cells trapped in intermediate stages of differentiation toward mononuclear cells such as monocytes, macrophages or DCs or polymorphonular granulocytes (Marigo et al., 2008).”
Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “In recent years, it has been demonstrated that arginase 1, which primarily metabolizes L-arginine into polyamine and proline, causes dysregulation of the T cell receptor (TCR) signal and subsequently induces CD8+ T cell unresponsiveness [77, 92].”
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia (2012, background): “Recent studies have indicated that Gr1+CD11b+ cells may contribute to tumor immune evasion by restraining the activity of CD8+ T cells (Gabrilovich and Nagaraj, 2009; Marigo et al., 2008).”
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. (2010, background): “Many strategies have been tested to dampen the immunosuppressive actions of MDSC, including treatments designed to favor their differentiation, or to inhibit their expansion or their inhibitory function (13, 38).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Their accumulation has been documented in most patients (15, 16) and mice (17) with cancer, where they are induced by various factors produced by tumor cells and/or by host cells in the tumor microenvironment (9, 18).”
Myeloid-derived Suppressor Cells Inhibit T Cell Activation by Depleting Cystine and Cysteine (2009, background): “MDSC immune effects have been attributed to the production of arginase, iNOS (36), and ROS (37) and to the nitration of TCRs (38).”