Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

By J. Hill, M. Feuerer, K. Tash, S. Haxhinasto, JA Perez, Rachel D. Melamed, D. Mathis, C. Benoist. Immunity, 2007

662 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ea91c7e50fbc12d7db3d8df99ee5e3b887b2fa14

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Citations in the corpus

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “Globally, 20% of these differentially expressed genes overlapped with the Treg cell signature (Hill et al., 2007), further linking IL-2R signaling with important aspects of Treg cells independent of Foxp3 expression.”
FOXP3+ regulatory T cells in the human immune system (2010, background): “Such 'induced' or 'adaptive' T Reg cells express many of the phenotypic markers associated with regulatory function, such as FOXP3, CD25 and CTLA4, but they do not exhibit the signature gene transcription profile of ex vivo natural CD4 + CD25 + FOXP3 + T Reg cells described in Ref”
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008, positive): “Taken together, our analysis suggests that PI3K/mTOR signaling controls not only Foxp3 and its direct targets, but a wider Treg-like transcriptional progam (30).”
A Special Population of Regulatory T Cells Potentiates Muscle Repair (2013, positive): “…population residing in nonlymphoid tissue, and dissimilarity to lymphoid-organ Treg cells, did not simply reflect a higher activation state in tissues, because few of the distinguishing transcripts were members of a previously determined Treg activation signature (Hill et al., 2007) (Figure 2C).”
Development and maintenance of regulatory T cells. (2013, background): “Consistently, ectopic retroviral transduction of Foxp3 in Tconv cells has failed to induce the expression of many Treg cell signature genes (Hill et al., 2007; Sugimoto et al., 2006).”
The blockade of immune checkpoints in cancer immunotherapy (2012, background): “33 ), the expression of which determines the T Reg cell lineag”
Regulatory T cells and immune tolerance. (2008, background): “Other genes, such as those encoding Granzyme B and the transcription factor Helios, are highly specific to Tregs but are apparently expressed independently of Foxp3 (Fontenot et al., 2005; Sugimoto et al., 2006; Hill et al., 2007).”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “…with contributing a distinct genetic sig- nature to T reg cells, Foxp3 conveys regulatory activity to nT reg cells, iT reg cells, and, upon ectopic expression, in con- ventional T cells (Schubert et al., 2001; Fontenot et al. 2003, 2005; Hori et al., 2003; Gavin et al., 2007; Hill et al., 2007).”
Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses (2014, methodology): “…within the TIGIT+/TIGIT comparison used previously determined gene sets: a T cell activation/proliferation signature from in vivo activated T cells (Hill et al., 2007); the canonical Treg/Tconv cell signature (Hill et al., 2007); a gene set that distinguishes Treg cells which express the chimeric…”
IL-17 and Th17 Cells. (2009, background): “Moreover, in microarray screenings that were undertaken to detect genes specifically upregulated in the Th17 or iTreg lineages, the aryl hydrocarbon receptor (AHR) was detected to be highly expressed in both the Th17 (80) and Treg signatures (81).”
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells (2012, background): “These two genes, for instance, are not part of the “T reg signature” established in previous publications (Hill et al., 2007; Lin et al., 2007).”
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo (2012, result): “S2). have been shown to be protective in some studies (Mottet et al., 2003; Huter et al., 2008; Haribhai et al., 2011) although others have reported less efficacy (Hill et al., 2007).”