An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

By C. Hsieh, Ye Zheng, Yuqiong Liang, J. Fontenot, Alexander Y. Rudensky. Nature Immunology, 2006

604 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/33097580047f6c34bc015b3834dd070ad7fe2bfc

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Citations in the corpus

A two-step process for thymic regulatory T cell development. (2008, methodology): “We purified T cells from the Foxp3+ Treg, and CD25hiGITRhi and CD25loGITRintFoxp3– CD4SP subsets, and we sequenced TRAV14 (Va2) chains as previously described (Hsieh et al., 2006).”
Foxp3 in control of the regulatory T cell lineage (2007, neutral): “These issues were addressed in studies using the aforementioned mixed Foxp3 − and wild-type bone-marrow transfers into irradiated or T cell–deficient hosts, and by the generation of TCR transgenic, RAG-deficient mice harboring wild-type or disrupted Foxp3 alleles in the presence or absence of t”
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 (2007, result): “That scenario is supported by the published observation that T reg cells express TCRs with an increased affinity for self peptide–major histocompatibility class II complexes and that in Foxp3 − mice, activated CD4 + T cells express TCRs frequently used by wild-type T reg cell”
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection (2009, background): “Given their high degree of self-reactivity, it is plausible that Treg cells can contribute to tissue damage or lose suppressive capacity if armed with effector cytokines (Hsieh et al., 2006).”
Regulatory T cells and immune tolerance. (2008, background): “…double α chains), sequence analyses of TCR Vα segments of a particular Vα subfamily in CD25 + or CD25 − CD4 + T cells have revealed distinct repertoires of the two populations, although the degree of overlap needs to be assessed more precisely (Hsieh et al., 2006; Pacholczyk et al., 2007).”
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells (2007, result): “have been complemented by T cell receptor (TCR) sequence analyses demonstrating a considerable overlap between thymic and peripheral T reg cell repertoire”
Regulatory T Cells and Foxp3 (2011, background): “On the other hand, the documented expression of self-reactive TCR by non-Treg cells and an overlap between self-reactive TCR repertoire displayed by Treg and non-Treg cells left open a possibility that Treg cell ablation in adults may be as severe as a congenital Treg deficiency in Foxp3-deficient m”
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. (2012, background): “, 2006), and TCR repertoire of Treg cells is different from that of peripheral Tconv cells (Hsieh et al., 2006).”
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice (2007, background): “In Foxp3-deficient mice, many activated T cells express TCRs normally found in T reg cells in wild-type mic”
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse (2011, background): “This is consistent with TCR repertoire studies (Hsieh et al., 2006; Pacholczyk et al., 2006), which showed that some clones are unique to Treg cells, some are unique to Tconv cells, and some are shared.”
Foxp3 instability leads to the generation of pathogenic memory T cells in vivo (2009, neutral): “The efficiency of the T reg system is a consequence of T reg cell expression of a TCR repertoire biased towards self-recognition16, 28,29.”
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007, background): “It was suggested that the encounter with autoantigens was required for their maintenance in vivo”