Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

By S. Kaech, Joyce T. Tan, E. Wherry, B. Konieczny, C. Surh, Rafi Ahmed. Nature Immunology, 2003

2,112 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9faee360fdce6e9030e893656cd540a052f2a54a

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In Immunology

1. Rafi Ahmed
2. E. Wherry
3. S. Kaech
4. M. Bevan
5. Bali Pulendran
6. Erika L. Pearce
7. F. Sallusto
8. A. Lanzavecchia

Citations in the corpus

• Memory CD8 T-Cell Differentiation during Viral Infection (2004, background): “This population of CD127Hi effector CD8 T cells, which constitutes 5 to 10% of the effector pool, preferentially survives and differentiates from effector CD8 T cells with an activated phenotype, high levels of granzyme B, and low levels of Bcl-2 into memory CD8 T cells characterized by a resting ph”
• Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8+ T Cell Memory Development (2011, background): “Additionally, it has been shown that Ag-specific CD8+ cells that have not fully differentiated into terminal Teff cells during primary infection express IL-7R and persist as long-lived memory T cells (Kaech et al., 2003).”
• Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. (2008, background): “IL-15, which can directly bind to IL-15Rα on T cells or be transpresented by IL-15Rα–bearing cells (38), may be the initial stimulus that enables survival of TCM-derived cells in vivo, although the later acquisition of IL-7Rα on transferred T cells is consistent with a role for IL-7 in the reversion”
• Signals required for programming effector and memory development by CD8+ T cells (2006, result): “This idea would be consistent with the recent demonstration that only the cells that re-express IL-7 receptor following a response to LCMV infection are competent to become memory cells (65).”
• Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. (2010, background): “Consistent with previous observations in the field, this early analysis of MP and TE subsets confirms that superior IL-2 production is a unique property of MP cells at different times of differentiation (Joshi et al., 2007; Kaech et al., 2003; Marzo et al., 2005; Sarkar et al., 2008; Wherry et al., ”
• Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “Consistent with this, newly emerging memory CD8 T cells express IL7R (Kaech et al., 2003).”
• CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “Are naive CD8 + T cells programmed early during the expansion phase by CD4 + T cell help to become productive memory cells? Or do CD4 + T cells provide an important contribution in the maintenance of memory CD8 + T cell numbers later during the memory phase? Expression of the interleukin 7 re”
• Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function (2005, background): “The size of naive and memory T cell pools is tightly regulated, at least in part, by growth and survival signals conferred by � c -dependent cytokines (7, 8). IL-7 is crucial for the survival and homeostatic expansion of naive CD8 � T cells and also can contribute to memory CD8 � T cell homeostasis ”
• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “Although a selective population of primed T cells re-expresses IL-7R&alpha”