Shaping and reshaping CD8+ T-cell memory

By J. Harty, V. Badovinac. Nature reviews. Immunology, 2008

627 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c552eb7b087273952188c097f760d2735894d0de

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In Immunology

Citations in the corpus

Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8+ T Cell Memory Development (2011, background): “…undergo a developmental program characterized by distinct phases encompassing first the expansion, and then contraction, of Ag-specific effector T (Teff) cell populations, followed by the persistence of long-lived memory T cells that mediate immunity to reinfection (Harty and Badovinac, 2008).”
Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development (2014, background): “Upon infection, activated CD8 T cells undergo a distinct pattern of differentiation characterized by the proliferation of antigen (Ag)-specific effector T (Teff) cells, followed by contraction of these cells and development of long-lived memory T cells (Cui and Kaech, 2010; Harty and Badovinac, 2008”
Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding (2016, methodology): “These experiments created commonly used working deﬁnitions of naive, memory, effector, and terminally differentiated subtypes of T cells (16, 17), along with the addition of other differentiation markers such as CD127 and KLRG-1(18–20).”
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, neutral): “A small proportion survives and persists asmemory Tcells that protect the host long-termagainst reinfection with the same pathogen (Harty and Badovinac, 2008; Williams and Bevan, 2007).”
Tissue-Resident Memory T Cells (2014, background): “…productively primed within SLOs, they give rise to effector cells that migrate throughout the host and leave behind a memory population that persists long after pathogen clearance (Dutton et al., 1998; Harty and Badovinac, 2008; Lefrançois, 2006; Sallusto et al., 2010; Williams and Bevan, 2007).”
Mechanisms of resistance to immune checkpoint inhibitors (2018, background): “…control), a subset of effector T cells must differentiate into effector memory T cells (TEM) (Ribas et al, 2016b), under the guidance of CD4þ helper T cells and dendritic cells; these are maintained for life and respond to re-challenge with antigen (Harty and Badovinac, 2008; Farber et al, 2014).”
NK cell development, homeostasis and function: parallels with CD8+ T cells (2011, background): “This resembles the contraction phase observed when effector T cells undergo activation-induced cell deat”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “inflammatory cytokines secretion influence the functional orientation and the strength of the acquired immune response, so that elevated or prolonged secretion of pro-inflammatory cytokines potentiates rapid acquired immune response (T-effector cells) at the cost of long-term protection (T-memory ce”
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “During acutely resolved infections, a highly proinflammatory environment promotes Teff development, including KLRG-1+, short-lived effector cells, whereas memory precursors and Tmem cells develop in a less proinflammatory environment (139, 140).”
Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism (2009, neutral): “Farrar and bred to OT-ITRAF6CD4-cre(1) mice to generate control OT-I-CA-St5TRAF6CD4-cre(2) mice (OTI-CA-St5-TRAF6-WT) and OT-I-CA-St5TRAF6CD4-cre(1) mice (OTI-CA-St5-TRAF6-DT).”
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1 (2010, background): “The transition of effector to memory CD8+ T cells is affected by extracellular stimuli including the strength and timing of stimulatory signals derived from T cell receptor (TCR)antigen interactions, costimulation, and inflammatory cytokines including interferons and IL-12 (Harty and Badovinac, 2008”