Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
By Daniel B. Stetson, M. Mohrs, R. Reinhardt, J. Baron, Zhi-En Wang, L. Gapin, M. Kronenberg, R. Locksley. Journal of Experimental Medicine, 2003
694 citations recorded by the source corpus.
Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-γ gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/faa60d08f35795f47beadcfae659af5f7ec232c0
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Citations in the corpus
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