Helping the CD8+ T-cell response

By M. Bevan. Nature reviews. Immunology, 2004

887 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7a06abff81abbc8eab1d61fbb7c713a8203d8ad9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Homeostasis of naive and memory T cells. (2008, background): “Notably, both types of memory cells are dependent on ‘‘help’’ from CD4 T cells during priming to undergo optimal differentiation into protective memory cells (Bevan, 2004).”
CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “…in activating the APC is required for the generation of the CD8 + primary response to noninﬂammatory antigens and certain viral infections such as herpes simplex virus (HSV), whereas the primary CD8 + response to inﬂuenza, Listeria , and LCMV infection is CD4 + T cell independent (Bevan, 2004).”
Shaping and reshaping CD8+ T-cell memory (2008, background): “One long-standing observation is the requirement for CD4 + T-cell 'help' for CD8 + T-cell memor”
CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “However, exactly what the requirements of T cell help are in vivo are still being debated (2), but we report here that IL-2 plays an important role in the breakdown of self-tolerance to a persisting Ag.”
Simultaneous Activation of Viral Antigen-specific Memory CD4+ and CD8+ T-cells Using mRNA-electroporated CD40-activated Autologous B-cells (2006, background): “Because it has been demonstrated that the expansion of both CD4 and CD8 T-cell responses is beneficial for the induction or reactivation of a robust memory cellular immune response, the simultaneous induction of CD4 and CD8 T-cell responses using the mRNA strategy would combine the advantages of bot”
Signals required for programming effector and memory development by CD8+ T cells (2006, background): “The dual roles of CD4 T cells in providing help in the early stages of the CD8 T-cell response and the variability of the requirements for this help, depending on the nature of the antigenic stimulus, together with the requirement of CD4 T cells for long-term maintenance of the memory cells, probabl”
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans (2012, neutral): “5 (35–248) 2 (26) NP NP08 48–65 KLSDHEGRLIQNSLTIEK 4 26 1 (13) NP NP14 95–111 PIYRRVDGKWMRELVLY 4 113 (45–181) 2 (26) NP NP15 102–119 GKWMRELVLYDKEEIRRI 4 93 (45–141) 2 (26) NP NP16 110–29 LYDKEEIRRIWRQANNGEDA 4 18 1 (13) NP NP20 141–156 SNLNDATYQRTRALVR 8 391 1 (13) NP NP21 147–163 TYQRTRALVRTGMDPR”
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity (2012, background): “CD8 + T cells have a pivotal role in antiviral immunity in target tissue”
CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review (2018, background): “The cells are roused from a quiescent state to the effector antigen‐specific killer cells (Bevan, 2004).”