Death by a thousand cuts: granzyme pathways of programmed cell death.

By Dipanjan Chowdhury, J. Lieberman. Annual Review of Immunology, 2008

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Pyroptosis in inflammatory diseases and cancer (2022, background): “However, there are many reports have shown that GZMA fails to kill target cells in vitro unless very high concentrations are used [44-46].”
How Do Cytotoxic Lymphocytes Kill Cancer Cells? (2015, background): “Several GZMs, including human and mouse GZMA, GZMB, GZMK, and GZMM, as well as human GZMH or mouse GZMC, have been shown to induce cell death in vitro by using purified molecules (6, 8, 18).”
Metformin promotes antitumor immunity via endoplasmic reticulum-associated degradation of PD-L1 (2018, neutral): “CD8CTL, the major effector of antitumor immunity, eliminates cancer cells by secreting granzyme B (GB), an apoptosis trigger (Chowdhury and Lieberman, 2008).”
Role of pyroptosis in inflammation and cancer (2022, background): “Granzyme B is also the most abundant granzyme in cytotoxic granules and is transported to cancer cells, where it cleaves caspase-3 and perforin to induce apoptosis [128, 129].”