Lineage relationship and protective immunity of memory CD8 T cell subsets

By E. Wherry, V. Teichgräber, Todd C. Becker, D. Masopust, S. Kaech, R. Antia, U. V. von Andrian, Rafi Ahmed. Nature Immunology, 2003

2,116 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/74ef4f000693d490ad27f80b0fe9f0e3797c1bea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rafi Ahmed
2. N. Restifo
3. S. Rosenberg
4. F. Sallusto
5. A. Lanzavecchia
6. K. Araki
7. S. Kaech
8. V. Badovinac

Citations in the corpus

• Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. (2005, result): “Our results are consistent with the report that in preventive infectious models, the adoptive transfer of “central memory” CD8+ T cells that possess enhanced lymphoid-homing properties and higher levels of the costimulatory molecule CD27 provides superior immunity compared with the transfer of CD62L”
• From Vaccines to Memory and Back (2010, positive): “In the case of T cells this model is supported by the findings that long-term reconstitution capacity is characteristic of T CM rather than T EM cells (Wherry et al., 2003) and by the prospective isolation of a putative memory stem cell (Gattinoni et al., 2009; Turtle et al., 2009).”
• Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. (2013, positive): “…studies using adoptive transfer of purified CD8 + T cell populations have revealed that less-differenti-ated Tscms and Tcms can mediate enhanced antitumor (4, 5) and antiviral (6) responses compared with more-differentiated Tems and Teffs, due to increased proliferative and survival capacities.”
• Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007, background): “…on the attribute examined, differ according to their localization, effector functions or potential to become protective memory CD8 T cells (de Bree et al., 2005; Huster et al., 2004; Kaech et al., 2003; Sallusto et al., 1999; Schluns et al., 2000; Voehringer et al., 2001; Wherry et al., 2003).”