Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

618 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Bcl6 dependent T follicular helper cell differentiation diverges from effector cell differentiation during priming and depends on the gene Icos (2011, neutral): “IL2RahiCD8+ T cells express Blimp1 more than their IL2Raint counterparts and consequentially are biased to differentiate into terminal effector CD8+ T cells (SLEC) (Kalia et al., 2010; Pipkin et al., 2010).”
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, neutral): “This corresponds to the very transient nature of CD25 expression, which is undetectable at the peak of the expansion phase, rendering the cells unresponsive to IL-2 (Kalia et al., 2010).”
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “We showed that increasing IL-2R 86 Immunity 32, 79–90, January 29, 2010 ª2010 Elsevier Inc. are consistent with those of an accompanying study (Kalia et al., 2010) reporting that viral infection induces some effector cells to express more IL-2Ra for a longer duration than others and that these…”
CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “Another study reports that whereas CD25 expression is uniformly high on antigen-speciﬁc CD8 + Immunity 35 , August 26, 2011 ª 2011 Elsevier Inc. 163 Immunity Review T cells early during LCMV infection, a biphasic expression pattern is evident by day 3.5–5 postinfection (Kalia et al., 2010).”