Memory CD8 T-Cell Differentiation during Viral Infection

By J. Wherry, Rafi Ahmed. Journal of Virology, 2004

992 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/83e51a3d6cdd21406af756a4c86b7381fd484bcc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. E. Wherry
2. Rafi Ahmed
3. A. Schietinger
4. P. Greenberg
5. G. Freeman
6. Arlene H. Sharpe
7. S. Kaech
8. K. Araki

Citations in the corpus

• PD-1 and its ligands in tolerance and immunity. (2008, background): “Viruses that cause chronic infections can render virus-specific T cells nonfunctional and thereby silence the antiviral T cell response (88).”
• T cell exhaustion (2011, background): “During exhaustion, loss of function occurs in a hierarchical manner, with exhausted CD8 + T cells losing some properties before losing other”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, methodology): “A second situation that can dramatically alter memory CD8 T cell differentiation is persisting infection (Klenerman and Hill, 2005; Wherry and Ahmed, 2004) (Figure 3 and Table 1).”
• Shaping and reshaping CD8+ T-cell memory (2008, background): “This may result in the deletion of CD8 + T cells of certain specificities or the exhaustion of their effector functions, without deletio”
• Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection (2010, background): “D chronic viral infection, virus-specific CD8 T cells become unresponsive to viral antigens and persist in a nonfunctional exhausted state (1).”
• Tolerance and Exhaustion: Defining Mechanisms of T cell Dysfunction (2013, positive): “High antigen load, long duration of the infection, and absence or loss of CD4 T cell help amplify the stage and severity of exhaustion, reflected in increasingly more profound functional impairment, distinct patterns of co-expression of inhibitory receptors, and higher expression levels of individua”
• Coregulation of CD8+ T cell exhaustion during chronic viral infection by multiple inhibitory receptors (2008, background): “1679" language="eng" relation="no"> After acute viral infection, memory CD8 + T cells rapidly reactivate effector functions, have high proliferative potential and are maintained by antigen-independent homeostatic proliferatio”
• The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection (2007, background): “Memory T cells gain the ability to persist in an antigen-independent way through IL-7- and IL-15-driven homeostatic proliferatio”