Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase.

By Madhav Sharma, B. Baban, P. Chandler, Deyan Hou, Nagendra Singh, H. Yagita, M. Azuma, B. Blazar, A. Mellor, D. Munn. Journal of Clinical Investigation, 2007

804 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/022cdd1f7dd478bc6a81badc9b98d308e31a9439

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In Immunology

1. Lieping Chen
2. W. Zou
3. G. Freeman
4. Arlene H. Sharpe
5. J. Wolchok
6. James P. Allison
7. D. Munn
8. A. Mellor

Citations in the corpus

• Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “In some of these studies, however, the phenotypic definition of pDCs can be questioned; for instance, the indoleamine 2,3-dioxygenase-expressing pDCs in tumor-draining lymph nodes (108) likely correspond to B cells with a similar phenotype (112).”
• IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance (2016, positive): “) This PD-1!PTEN feedback loop thus provides a molecular explanation for the earlier observation, seen in multiple models, that IDO-induced Treg activity is strictly dependent on the PD-1/PD ligand pathway to create suppression [67,83,96,97].”
• Inhibitory B7-family molecules in the tumour microenvironment (2008, background): “Importantly, the ability of these T Reg cells to suppress T-cell activation could be abrogated by antibody specific for B7-H1 (Ref”
• PD-1 and its ligands in tolerance and immunity. (2008, background): “The suppressive activity of IDO-treated regulatory T cells required cell contact with IDO-expressing DCs and was abrogated by PD-L blockade (140).”
• Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4 (2013, background): “In addition to being constitutively expressed by many malignant cells (Muller et al., 2005a), IDO can be induced in tumor cells and APCs by proinflammatory stimuli such as IFN-, which is generated by the host immune response against the tumor (Taylor and Feng, 1991; Belladonna et al., 2009).”
• Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies (2019, background): “This enzyme can be expressed not only by macrophages but also in dendritic cells 670 (DCs), and IDO + DCs in mammals can potently and dominantly be suppressive for T 671 cell activation (Sharma et al., 2007).”