Indoleamine 2,3 dioxygenase and metabolic control of immune responses
By D. Munn, A. Mellor. Trends in immunology, 2012
966 citations recorded by the source corpus.
Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to stimuli. By catabolizing the essential amino acid tryptophan, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent local effects on innate and adaptive immune responses to inflammatory insults. Here, we discuss recent progress in elucidating how IDO activity promotes local metabolic changes that impact cellular and systemic responses to inflammatory and immunologic signals. These recent developments identify potential new targets for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.
Subfields: Behavioral Neuroscience, Biological Psychiatry, Endocrine and Autonomic Systems
View Paper: https://www.semanticscholar.org/paper/68af154ad5e51582917bb2962c9d502e7fe88378
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In Biological Psychiatry
Citations in the corpus
- Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024, background): “236 In the brain, KYN is metabolized to the neurotoxic substance quinolinic acid (QUIN).”
- Metabolic competition in the tumor microenvironment is a driver of cancer progression (2015, background): “Tumor cells can express indoleamine 2,3-dioxygenase, an enzyme that depletes tryptophan and inhibits T cell proliferation (Munn and Mellor, 2013; Munn et al., 1999).”
- IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance (2016, neutral): “In 2013 in this journal, we reviewed the role of IDO in creating metabolic signals that regulate immune responses [36].”
- Immunotherapy for glioma: current management and future application. (2020, neutral): “Indoleamine 2,3-dioxygenase (IDO) is an inducible, rate-limiting enzyme in tryptophan catabolism, with the immunomodulatory function of reducing the activity of T cells [48].”
- Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies (2019, background): “…by IDO, due to important biological effects carried out by kynurenine 778 metabolites on the immune response (Grohmann et al., 2003; Moffett & Namboodiri, 779 2003b; Munn & Mellor, 2013) which makes this not only a tryptophan degradative 780 pathway but an important biosynthetic pathway, too.”
- Metabolic Pathways In Immune Cell Activation And Quiescence (2013, background): “The utilization of this pathway depletes tryptophan in the microenvironment, and, with the production of immunosuppressive catabolites, negatively effects T cells function and survival (Mellor and Munn, 2004; Munn and Mellor, 2013; Platten et al., 2012; Serhan et al., 2011; Zhao et al., 2012).”