Indoleamine 2,3-dioxygenase and tumor-induced tolerance.

By D. Munn, A. Mellor. Journal of Clinical Investigation, 2007

1,038 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/a9e815433be4748cbf26eced207fd773d416b793

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. A. Mellor
2. D. Munn

In Biological Psychiatry

1. D. Munn
2. A. Mellor
3. W. Zou

In Psychiatry and Mental health

1. A. Mellor
2. D. Munn

Citations in the corpus

• Tumor cell metabolism: cancer's Achilles' heel. (2008, background): “IDO overexpression has been implicated in cancer-associated anorexia/cachexia (Munn and Mellor, 2007), and kynurenine produced by tumor cells can kill CTLs by apoptosis (Puccetti and Grohmann, 2007).”
• Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, background): “Thus, IDO is emerging as a potentially important tolerogenic mechanism in patients with cancer (8).”
• The tumor microenvironment and its role in promoting tumor growth (2008, background): “Another enzyme that might be produced by MSC is indoleamine-2,3-dioxygenase (IDO) involved in the catabolism of tryptophan, an essential amino acid for T-cell proliferation and differentiation (Munn and Mellor, 2007).”