The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
By Xin Yu, Kristin Harden, Lino C. Gonzalez, M. Francesco, E. Chiang, B. Irving, I. Tom, S. Ivelja, C. Refino, H. Clark and 2 more. Nature Immunology, 2009
1,361 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/42b4c061aff44f9ccdeac327de516ce83bb075a2
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In Immunology
- Alexander Y. Rudensky
- Steven Z. Josefowicz
- Li-Fan Lu
- F. Quintana
- Arlene H. Sharpe
- V. Kuchroo
- D. Mathis
- C. Benoist
Citations in the corpus
- Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 (2019, background): “The protein includes an extracellular IgV region, a transmembrane domain, and a cytoplasmic tail that harbors a canonical ITIM and an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif [22].”
- Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc (2016, background): “Fap2 binds and activates TIGIT (Yu et al., 2009) an immunoregulatory signaling receptor in T cells and NK cells.”
- Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “Upon Treg cell interactions with dendritic cells, TIGIT appears to induce production of immunosuppressive cytokines IL-10 and TGF-β by dendritic cells (212).”
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity (2009, background): “Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M (2004) Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).”
- Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging (2018, background): “It is expressed on NK cells, CD8+ T cells, and CD4+ T cells (94), is induced upon activation in multiple immune cell subsets (95–97), and its expression marks exhausted CD8+ T cells in HIV and SIV infection (49).”