Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

By Lieping Chen. Nature reviews. Immunology, 2004

1,336 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ce0a9d39fc723de779113456c36a328dc304156a

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Citations in the corpus

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 (2019, background): “Structural analysis shows that the IgV domain of VISTA shares a sequence homology both to CD28 and B7 families, while the fulllength VISTA harbors a highest identity with PD-1 [115].”
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma (2006, background): “The ovarian cancer microenvironment presents an overwhelming arsenal of actively tolerizing mechanisms, including an imbalance of plasmacytoid versus myeloid DCs (11), costimulatory molecules versus coinhibitory molecules (this work) (10, 25), and regulatory versus eff ector T cells (26).”
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. (2005, background): “B7-H1 could be stimulatory and inhibitory for T-cell functions, perhaps due to ligation of different receptors as well as reverse signaling of B7-H1 to T cells (16, 17).”
Regulation of PD-L1: a novel role of pro-survival signalling in cancer. (2016, neutral): “2) on the APC (Figure 1) [18].”
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency (2015, neutral): “way is a negative feedback system that represses Th1 cytotoxic immune responses and that, if unregulated, can damage the host.(1-3) It is up-regulated in many tumors and in their surrounding microenvironment.”
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection (2007, background): “dtd" [ ]> The receptor 'programmed cell death 1' (PD-1; also called CD279) is inducibly expressed on CD4 + T cells, CD8 + T cells, natural killer T cells, B cells and activated monocyte”
Helminth parasites – masters of regulation (2004, background): “This signal induces them to increase indoleamine 2,3-dioxygenase, which in turn leads to the inhibition of T-cell responses (128).”
Restoring function in exhausted CD8 T cells during chronic viral infection (2006, positive): “The PD-1 inhibitory pathway is known to regulate immune responses to self antigens 11–13 .”
Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, positive): “Therefore, we engineered synNotch T cells that drive the simultaneously production of paracrine inhibitory signal such as the cytokine, IL-10, and the T cell inhibitory ligand, PD-L1, which could drive cell-to-contact inhibition (Chen, 2004; Ouyang et al., 2011).”
Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. (2006, background): “Within the last decade, it has become evident that T-cell activation, T-cell inactivation, and T-cell death are ultimately governed by the balance between positive and negative T-cell costimulatory signaling (4).”
Inhibitory B7-family molecules in the tumour microenvironment (2008, background): “; and high levels of expression of inhibitory B7 molecules by APCs, stromal cells and tumour cell”