Regulation of mTORC1 by amino acids

By L. Bar-Peled, David M. Sabatini. Trends in Cell Biology, 2014

760 citations recorded by the source corpus.

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases, including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of the Rag GTPases and Ragulator, v-ATPase, GATOR and Folliculin complexes. An increased understanding of this pathway will not only provide insight into growth control, but also into the human pathologies triggered by its deregulation.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3d7e31ed1c1029e51ac95d8b6add82a7699758a9

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Citations in the corpus

• Mechanisms of Autophagy Initiation (2017, background): “mTORC1 (TORC1 in yeast) is a master regulator of cell growth and metabolism, and its inactivation in response to amino acid depletion is a major trigger for autophagy (50).”
• Branched Chain Amino Acids: Beyond Nutrition Metabolism (2018, background): “The mTOR is the central regulator of mammalian cell growth [16], proliferation and migration [17], hypertrophy [18], IR [19] as well as pathogenesis of many other human diseases and survival, and is an evolutionary conserved serine/threonine protein kinase in the PI3K-related kinase (PIKK) family [2”
• Nutrient sensing and TOR signaling in yeast and mammals (2017, neutral): “Amino acid sufficiency regulates TORC1 via different mechanisms that largely involve the conserved RAG family of small GTPases (for review, see Jewell et al , 2013; Bar-Peled & Sabatini, 2014; Shimobayashi & Hall, 2015; Hatakeyama & De Virgilio, 2016; Powis & De Virgilio, 2016; Fig 1).”
• mTOR: a pharmacologic target for autophagy regulation. (2015, neutral): “33, 34).”