mTOR signaling at a glance

By M. Laplante, David M. Sabatini. Journal of Cell Science, 2009

2,286 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/33a3bd551f7b03530a2fdabf9040e0f021a13a8e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Erika L. Pearce
2. David M. Sabatini
3. L. Bar-Peled
4. M. Laplante
5. Russell G. Jones
6. Roberto Zoncu
7. G. V. D. van der Windt
8. C. Piccirillo

In Molecular Biology

1. David M. Sabatini
2. M. Laplante
3. L. Bar-Peled
4. Roberto Zoncu
5. Ralph J. Deberardinis
6. Erika L. Pearce
7. Y. Sancak
8. Russell G. Jones

Citations in the corpus

• The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. (2015, background): “Finally, we assessed whether the genetic ablation of Raptor, a scaffolding protein for mTORC1 (Laplante and Sabatini, 2009), in T cells would rescue the defect in primary responses by AMPKa1-deficient T cells in vivo.”
• Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions (2014, background): “mTOR activation regulates a myriad of cellular functions, including growth, apoptosis, differentiation, and metabolism (31, 32).”
• The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling (2011, background): “The complex mTORC1 contains the scaffolding protein Raptor, as well as the subunits mLST8, PRAS40 and Depto”
• Regulation of Immune Responses by mTOR (2011, background): “mTORC2 also contains mLST8 and DEPTOR in addition to the scaffolding protein RAPTOR-independent companion of TOR (RICTOR), mSIN1 proteins, and the protein observed with RICTOR (PROTOR) (11).”
• Complement System Part II: Role in Immunity (2015, background): “It is important to note that AKT (PKB) andmTORbelong to the same signaling cascade, which has anti-apoptotic, survival, and proliferation effects (29).”
• Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “1,38 This has been observed that dysregulated oncogenes, enhanced anabolism, angiogenesis, and suppression of autophagy underlie the tumorigenic behavior of mTORC1. mTORC2 is activated by growth factors which in turn activates AKT and AGC family leading to increased cellular proliferation and…”
• Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “Other factors including oxygen, energy, inflammation, Wnt signaling and phosphatidic acid have also been identified as regulators of mTORC1 (reviewed by Laplante and Sabatini, 2009).”
• In brief (2011, neutral): “, 2002), are conserved across all eukaryotes and regulate a wide spectrum of cellular processes that mediate cell growth (Laplante and Sabatini, 2009; Soulard et al., 2009; Wullschleger et al., 2006; Yang and Guan, 2007).”
• Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids (2010, methodology): “the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids”
• AMPK is a negative regulator of the Warburg Effect and suppresses tumor growth in vivo (2012, background): “TORC1 is a central regulator of cell size (Laplante and Sabatini, 2009), and AMPK cannegatively regulate TORC1activity under energy stress (Inoki et al., 2003; Shaw et al., 2004a).”
• ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “Recent studies have revealed that association of mTOR with Raptor or Rictor defines two different mTOR-containing signaling complexes, which are designated mTORC1 and mTORC2, respectively (182).”