Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

By Monther Abu-Remaileh, Gregory A. Wyant, Choah Kim, N. N. Laqtom, M. Abbasi, Sze Ham Chan, Elizaveta Freinkman, David M. Sabatini. Science, 2017

618 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/99f11402958025c5a1dc616c4e481461dc34dcd8

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In Cell Biology

1. Elaine Lin
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In Epidemiology

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Citations in the corpus

• Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I (2020, positive): “For lysosome immunoprecipitation experiments, HPDE and human PDAC cell lines stably expressing TMRHA were ruptured and intact lysosomes from 1–2 mg of total protein per sample was immunoprecipitated using HA-conjugated Dynabeads as previously described 45,46 .”