Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses

By S. Seong, P. Matzinger. Nature reviews. Immunology, 2004

1,239 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c6328687b0ffb7fba4e5f6ee56a2002e3f6bc57e

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. O. Takeuchi
4. Satoshi Uematsu
5. R. Medzhitov
6. J. Tschopp
7. H. Kono
8. Fabio Martinon

In Molecular Biology

1. Shizuo Akira
2. J. Tschopp
3. Taro Kawai
4. H. Kono
5. K. Rock
6. D. Tang
7. Fabio Martinon
8. R. Kang

Citations in the corpus

• Cytokines in Inflammatory Disease (2019, background): “Inflammation-inducing pathogen-associated molecular patterns (PAMPs) include highly conserved structures [3] such as cytosine-phosphate-guanin motifs [4], heat shock proteins (HSP), peptidoglycans (PGN), and lipopolysaccharides (LPS) [5], while danger-associated molecular patterns (DAMPs) are origin”
• Inflammatory responses and inflammation-associated diseases in organs (2015, background): “DAMPs are host biomolecules that can initiate and perpetuate a noninfectious inflammatory response [12].”
• Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “In fact, both pathogen-induced and danger signals ligate common receptors (Seong and Matzinger, 2004).”
• Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. (2012, background): “The immune system uses a large number of highly conserved pattern recognition receptors to detect either exogenous molecules associated with pathogens or endogenous molecules generated in response to cell and tissue injury (Janeway and Medzhitov 2002; Seong and Matzinger 2004).”
• Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (2007, background): “This entire response to danger needs to be coordinated at the tissue level, involving interactions between many different cell types, and presumably interactive networks have evolved to meet this challeng”
• Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “The same molecules of the innate humoral immune system react with hydrophobic surface”
• The inflammasomes: guardians of the body. (2009, background): “Matzinger P. 2002.”
• Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. (2006, background): “However, the innate immune system could use this mechanism to sense danger represented by inflamed or remodeled tissues (Seong and Matzinger, 2004).”
• Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy (2007, background): “HMGB1 release by dying tumor cells Reportedly, a number of endogenous proteins bind and stimulate TLR”
• Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites (2013, background): “Hydrophobic surfaces are considered to represent damage-associated molecular patterns (DAMPs) that nonspecifically activate the innate immune response (48).”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “In this model, antigen-presenting cells are activated by PAMPs and DAMPs from stressed or damaged tissues or microbes (65).”