Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.

By Y. Nagai, K. Garrett, S. Ohta, U. Bahrun, T. Kouro, Shizuo Akira, K. Takatsu, P. Kincade. Immunity, 2006

876 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/67be4c7f17f22dafce83b04f8388b177e0f0ee4a

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In Immunology

Citations in the corpus

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool (2011, result): “Notably, other studies have found that hematopoietic stem or progenitor cells can generate myelomonocytic cells in peripheral tissues in response to Toll-like receptor signalin”
Steady-state and inflammatory dendritic-cell development (2007, background): “The Toll-like receptors (TLRs) for microbial products are expressed at early stages of haematopoiesis and their ligation can deflect the normal pathways of differentiation towards increased DC developmen”
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity (2018, background): “…systemic inflammation induces hematopoietic progenitor expansion, which facilitates the restoration of BM cellularity and compensates for the increased need for mature myeloid cells (Mitroulis et al., 2017; Nagai et al., 2006; Takizawa et al., Cell 172, 147–161, January 11, 2018 151 2017).”
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype (2010, result): “Our observations support a recent finding that transforming growth factor-β–activated kinase-1, a downstream mediator of TRAF6, and TLR4 activation is important for HSPC maintenanc”
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. (2007, background): “…immunity during life-threatening infections, where microbial components either access the circulation and reach the BM or where dispersed stem and progenitor cells sense foreign materials outside the marrow compartment and become locally converted to innate effector cells (Nagai et al., 2006).”
microRNA regulation of inflammatory responses. (2012, background): “Additionally, TLR expression has been found in hematopoietic stem and progenitor cells and TLR4 activation can lead to activation of MyD88 signaling and myeloid differentiation of these cells (89).”