The inflammasomes: guardians of the body.

By Fabio Martinon, Annick Mayor, J. Tschopp. Annual Review of Immunology, 2009

2,435 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5e9a7010254584e3c23c70eb455b5810d33b83c5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Immunology

In Molecular Biology

Citations in the corpus

The sterile inflammatory response (2010, background): “NALP1 is the only NALP family member that contains both a PYD domain and a CARD domain, the latter of which can recruit caspase-5 (76).”
Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery. (2017, neutral): “NLRP3 (and some other NLRs) activate multiprotein complexes called inflammasomes that facilitate the production and release of inflammatory cytokines, IL-1β and IL-18.(93) Activation of the transcription factor nuclear”
Fatty Acid and Endotoxin Activate Inflammasomes in Mouse Hepatocytes that Release Danger Signals to Stimulate Immune Cells (2011, neutral): “danger signals, including uric acid crystals and amyloidb protein.(11) In response to danger signals, NALP3 inter-”
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. (2012, background): “, 2009), triggering autocatalytic activation of caspase-1 (Martinon et al., 2009).”
Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling (2015, background): “Upon receipt of defined sets of transcriptional and post-translational signals, inflammasomes are assembled, become active through auto-cleavage of pro-caspase-1, and process the catalytic activation of IL-1b and IL-18 (Martinon et al., 2009).”
The role of oxidative stress during inflammatory processes (2013, background): “Diverse crystals, including monosodium urate, calcium pyrophosphate dehydrate, and calcium oxalate, potently activate NLRP3 to induce joint inflammation in crystalinduced arthritis such as gout and pseudogout (Busso and Ea, 2012), as well as renal damage in crystalline nephropathy…”
NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice (2012, neutral): “Fig.1) consistent with chronic inflammasome activation 4 .”
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis (2017, background): “It is thought that caspase-1 plays a role in the exclusion of infectious substances and the exacerbation of inflammation by activating pyroptosis, a highly inflammatory form of programmed cell death [5].”
The IL-1 family: regulators of immunity (2010, background): “However, it is clear that IL-1β and IL-18 have pro-domains at their amino termini that require cleavage by a protein assembly known as the inflammasome to generate the biologically active forms and to be secrete”