Cytokines in Inflammatory Disease

By Shinwan Kany, Jan T Vollrath, B. Relja. International Journal of Molecular Sciences, 2019

1,680 citations recorded by the source corpus.

This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this review, we focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts (e.g., shock, trauma, immune dysregulation, osteoporosis, and/or critical illness).

Subfields: Hematology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/532dd0b10bf1d79c632bc6023a0c8c36cda3fb00

Citations in the corpus

• Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) (2020, neutral): “(30, 31), based on our (inverse correlation) results, we suggest that the secretion of these cytokines does not originate from T cells.”