Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.

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Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “Previous studies have indicated that pathogenesis of AD is associated with peripheral infectious origin, which can cause neuroinflammation in CNS [176, 177].”
Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models (2016, neutral): “Although microglia and complement activation are prominently involved in plaque maintenance and related peri-plaque neuropathology, their roles have heretofore been largely regarded as a secondary event related to neuroinflammation (2).”