Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer

By K. Liby, M. Yore, M. Sporn. Nature Reviews. Cancer, 2007

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Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “Nrf2 activators such as triterpenoids (CDDO-Im) that target cysteine residues of Keap1 have been used to specifically disrupt Keap1:Nrf2 interactions, thereby promoting Nrf2 nuclear accumulation and leading to Nrf2-target gene induction (247) in Nrf2-sufficient but not in Nrf2-deficient cells in vit”
Targeting mitochondria for cancer therapy (2010, background): “Betulinic acid (3b, hydroxy-lup-20(29)-en-28-oic acid) is a natural pentacyclic triterpenoid of the lupane class that is contained in various species throughout the plant kingdo”
Role of nrf2 in oxidative stress and toxicity. (2013, background): “In addition to being potent inducers of ARE genes and anticancer agents, cyano enone inducers exhibit strong anti-inflammatory, hypoglycemic, antihyperlipidemic, antiproliferative, and proapoptotic activities (97, 157).”
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. (2009, background): “Recent studies have shown that diets rich in phytochemicals can significantly reduce cancer risk by as much as 20% [2,31,32].”