Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

By M. Bachmann, G. Jennings. 2010

1,992 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Molecular Biology

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Citations in the corpus

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus (2019, background): “This effect is thought to derivemainly fromstrongerB cell activation through antigen-driven cross-linking of B cell receptors (BCRs) (Bachmann and Jennings, 2010), although potential effects on antigen trafficking and localization may also play a role (Irvine et al.”
Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “nanomaterial is also of critical importance since therapeutic nanoconstructs have dimensions very similar to those of pathogens for which recognition signals were positively selected for evolution [35].”
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers (2018, methodology): “(C, D) Unmodified eOD-60mer (1) and eOD-60mer deglycosylated by PNGase F treatment (2) were analyzed via SDS-PAGE gel for changes in subunit size and glycan content (C, left: nonspecific protein stain, right: glycoprotein stain), dynamic light scattering (D, eOD-60mer, red; deglycosylated eOD-60mer,”
HIV-1 envelope trimer fusion proteins and their applications (2016, positive): “The greater size and the capacity for multivalent antigen presentation and B cell receptor cross-linking provide such particulate vaccines with advantages over soluble proteins for inducing antibody responses [11].”
The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “Particulate CDCs possess characteristics — submicrometer size and repetitive surface architecture — similar to those of pathogens which can stimulate immunogenic reactions [179].”
Self-assembling protein nanoparticles in the design of vaccines (2015, positive): “A variety of naturally occurring proteins can self-assemble into nanoparticles that are highly symmetric, stable, and structurally organized, with diameters of 10–150 nm [9,10], a highly suitable size range for optimal interactions with various cells of the immune system [8,11].”
Engineering virus-like particles as vaccine platforms (2016, neutral): “Epitopes presented on the multivalent, highly repetitive, and often rigid structures of VLPs can extensively crosslink B cell receptors, leading to strong stimulation of B cells and the induction of robust and long-lasting antibody responses [3,4 ,5].”