Inflammatory responses and inflammation-associated diseases in organs

By Linlin Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Yinglun Li, Xun Wang, Ling Zhao. OncoTarget, 2015

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Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commonly the NF-κB, MAPK, and JAK-STAT pathways. Here, we review inflammatory responses within organs, focusing on the etiology of inflammation, inflammatory response mechanisms, resolution of inflammation, and organ-specific inflammatory responses.

View Paper: https://www.semanticscholar.org/paper/0288ad9ae5b644af3c0ba2c9ca15cb44e7eb2dfe