Selective autophagy mediated by autophagic adapter proteins

By T. Johansen, T. Lamark. Autophagy, 2011

1,728 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c4a17ed71262ab92bce352262e611926880cd2f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. N. Mizushima
2. V. Deretic
3. M. Komatsu
4. T. Johansen
5. T. Lamark
6. T. Yoshimori
7. P. Codogno
8. Koji Okamoto

In Epidemiology

1. N. Mizushima
2. V. Deretic
3. T. Johansen
4. Beth Levine
5. D. Klionsky
6. T. Lamark
7. M. Komatsu
8. I. Slaninová

In Molecular Biology

1. N. Mizushima
2. V. Deretic
3. M. Komatsu
4. T. Johansen
5. T. Lamark
6. Hozumi Motohashi
7. P. Codogno
8. T. Yoshimori

Citations in the corpus

• Autophagy in inflammation, infection, and immunometabolism (2021, background): “LC3 interacting region; LIR) (Johansen and Lamark, 2011; Marshall et al., 2019) that bind to mammalian Atg8 paralogs (mAtg8s: LC3A,B,B2,C and GABARAP, -L1, -L2), with LC3B being the prototypical marker for autophagic membranes (Figure 1A,D).”
• Emerging regulation and functions of autophagy (2013, background): “The latter interaction is mostly mediated through a specific amino acid sequence present in the autophagy receptors and commonly referred to as the LC3-interacting region (LIR) or the Atg8-interacting (AIM) motif 13, 14 .”
• Autophagy: Renovation of Cells and Tissues (2011, background): “Thus, it has been proposed that p62 may be an autophagy receptor for degrading ubiquitinated cargos, including ubiquitinated aggregates, damaged mitochondria, ubiquitinated midbody rings, ubiquitin-tagged peroxisomes, ubiquitinated microbes, ribosomal proteins, and virus capsid proteins (Johansen an”
• Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells (2011, background): “Although autophagy has generally been considered nonselective, recent studies have shed light on another indispensable role for basal autophagy in cellular homeostasis, which is mediated by selective degradation of a specific substrate(s) (Kirkin et al., 2009; Kraft et al., 2010; Johansen and Lamark”
• Molecular mechanisms and physiological functions of mitophagy (2021, positive): “…selective autophagy-related processes including mitophagy, a series of autophagy adaptors (p62/SQSTM1, NBR1, NDP52/ CALCOCO2, TAX1BP1, and OPTN) play important roles in selective uptake of cargoes (Johansen & Lamark, 2011; Mizushima & Komatsu, 2011; Stolz et al , 2014; Zaffagnini & Martens, 2016).”
• Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β (2011, background): “The principal components of the autophagic signalling and execution machinery are (i) a protein kinase network including Tor, AMPK, and Ulk1/2 (Egan et al, 2011; Kim et al, 2011), (ii) lipid kinases, principally the class III phosphatidylinositol 3kinase hVPS34 (Kihara et al, 2001) and potentially c”
• Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. (2014, background): “…identification and characterization of selective autophagy receptors, such as mammalian p62/SQSTM1 (sequestosome-1, also known as p62) and yeast Atg19, which link the cargo to the autophagic machinery and elicit directed autophagosome formation (Johansen and Lamark, 2011; Kirkin et al., 2009b).”
• Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. (2020, background): “A second function of lipidated ATG8 proteins is the LIR-dependent attachment of SARs (with our without cargo) to the inner (concave) surface of the phagophore [19,20].”
• Cellular senescence and its effector programs (2014, background): “Some level of specificity of the cargo for degradation is directed through autophagic receptors, including p62 (also known as sequestosome-1), NBR1, and Nix (Johansen and Lamark 2011).”
• Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013, background): “…and can associate with both the autophagosomelocalizing protein LC3 and ubiquitinated proteins (Bjørkøy et al., 2005); therefore, p62 is considered to act as a receptor for ubiquitinated proteins, organelles, and microbes, which it sequesters into the autophagosome (Johansen and Lamark, 2011).”
• The LIR motif – crucial for selective autophagy (2013, background): “It should also be noted that p62 has a role in mitophagy (Johansen and Lamark, 2011), although this process is primarily mediated by specific mitochondrial membrane receptors, as discussed below.”